Ive found that obsessing over nuances of tone is for dicking around at home by yourself. Often what sounds good at home by yourself just doesn't work in a band context. And yea, something dialed in sounding great one day often seems to suck the next. Hence my obsession with subtle differences in overdrive tones.
Live, pretty much any old OD will do as long as it boosts some mids and isn't muddy.
At home I pretty much hate bridge pickups. But at yesterdays jam I pretty much stayed on the Tele's bridge the whole time. Was running a small board Tele>TU3>Diamond Comp>Nobels>DM2w>Carr Rambler.
My preferred neck and middle tones were just too bassy/muddy and couldn't be heard over the din of other guitars.
Had to use the bass cut switch on the Noballs as well.