At about 220, I'm firmly in the 25.5" scale, but I agree with HIAR that neck shape has a lot to do with it, too. I also know that as I am adding more years, a shorter scale is feeling a little easier. I was shocked at how comfortable my PRS SE Custom 24 felt, which I had chalked up to the neck profile, and the very low action. It is possible, though, that since I have entered my 60's that my hands are less flexible, so that just a .5" difference in the scale length becomes quite noticeable. The 25.5" scale length is still ok for me at the moment, so the Strat will still be my primary guitar.