I like my Fender DRRI as my primary amp, so kind of a multi-channel tube amp, because it has a channel without effects, and one with. It also has different inputs for single coil guitars and humbucker guitars.
That said, I still like a my hybrid Tube Works amp - head and 2x cab. It's basically a 2 channel solid state amp, but it has a 12ax7 preamp tube that can be switch in for the distortion channel.
I did have a Fender Frontman 212R for a couple of years, and it sounded ok, but it just never seemed to have any character (I wouldn't quite call it "sterile'). Even with pedals, it just didn't quite do it for me.
Acoustic playing is totally different, though. For this, a solid state Crate Acoustic 125D, or a solid state Genz Benz Shenandoah 80 do just fine.