There were a lot fewer options available for lefties in the 50's and 60's, and by the time he 'made it', Jimi was probably quite comfortable playing them upside down. It also arguably added to his signature sound, at least on strats. The longer string length on the bass strings, as well as the reversed angle of the bridge pickup have been emulated by right handers trying to cop his sound. Whatever, it seemed to work for him. Plus, as I understand it, jimi played strats right off the music store hangers, with the nut swaped and the strap button moved to the other horn. No custom shop/artist series guitars.