Ok, after playing with it a bit, I can give some honest feedback from admittedly limited experience, but experience nonetheless.
First of all, there are 2 inputs on each channel (normal & vibrato) #1 on each channel would be the regular input, while input #2 is for "hotter instruments" and has a 6 db roll off. Using input #2 is where I plug in my humbucker guitars, with the exception of the Gretsch 5120, the Epi LP, and the Thinline Tele Deluxe with the Wide Range humbuckers. These seem to like the hotter #1 inputs.
Secondly, when it comes to the single coils, I will say that the '65 Deluxe Reverb totally loves the Vintage Noiseless pickups on the new MIM Deluxe Player's Strat, and the pairing is very bit what I had heard in the store. It also does well with the Lace Sensor Gold pups, but make sure to go easy on the reverb, because of the longer sustain of the Lace Sensors. What it doesn't seem to like is the MIM Standard single coils, which sound a little flat through this amp.
All in all, this amp is still breaking in, so I expect more awesomeness as it does so. In the meantime, I can say that it has enough low end to bring out the growl in a humbucker, while still adding a little sparkle and shine. But if you're looking for the single coil chime, and the Fender sound, then this amp can get you there. Of course, if you're looking for single coil magic, you might want to pair it with Vintage Noiseless pups.